Felty syndrome
Would you like to know what lab results mean? DDxHub - Differential Diagnosis Hub helps to understand and explains your blood test.
Felty syndrome |
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Would you like to know what lab results mean? DDxHub - Differential Diagnosis Hub helps to understand and explains your blood test. |
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All information on this page is intended for your general knowledge only and does not provide medical advice, diagnosis or treatment. See Additional Information |
Felty syndrome is a rare disorder that involves rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections. It is more common in people who have had rheumatoid arthritis for a long time. People with this syndrome are at risk of infection because they have a low white blood cell count. This is a rare, extra-articular manifestation of rheumatoid arthritis (RA), characterized by persistent, idiopathic neutropenia and, in some cases, splenomegaly. Estimated to occur in <1% of RA patients. Tends to occur in the fifth to seventh decades of life, typically in white patients who have had long-standing seropositive, erosive RA. Cause of neutropenia is multifactorial and is thought to result from an imbalance between neutrophil production in the bone marrow and increased destruction in the peripheral blood, or both. A clinical diagnosis with no specific diagnostic test; other causes of neutropenia should be excluded. Goal of therapy is to raise the neutrophil count and prevent recurrent infections, while controlling systemic rheumatoid disease activity.
